PET in infancy predicts long-term outcome during adolescence in cryptogenic West syndrome.

ABSTRACT:

Background and purpose

Developmental and seizure outcomes in patients with cryptogenic West syndrome are variable. Our aim was to clarify the relationship between FDG-PET findings in infancy and long-term seizure and developmental outcome in cryptogenic West syndrome.

Materials and methods

From 1991 to 1999, we prospectively performed FDG-PET from the onset of cryptogenic West syndrome in 27 patients. PET was performed at onset and at 10 months of age. In 2012, we evaluated the educational status, psychomotor development, and seizure outcome in 23 of the 27 patients (13-22 years of age). The correlation between PET findings and outcome was evaluated.

Results

At onset, PET showed hypometabolism in 13 patients (57%). The second PET after the initial treatment revealed c

SUBMITTER: Natsume J 

PROVIDER: S-EPMC7964455 | biostudies-literature | 2014 Aug

REPOSITORIES: biostudies-literature