Differential diagnosis of normal pressure hydrocephalus by MRI mean diffusivity histogram analysis.

ABSTRACT:

Background and purpose

Accurate diagnosis of normal pressure hydrocephalus is challenging because the clinical symptoms and radiographic appearance of NPH often overlap those of other conditions, including age-related neurodegenerative disorders such as Alzheimer and Parkinson diseases. We hypothesized that radiologic differences between NPH and AD/PD can be characterized by a robust and objective MR imaging DTI technique that does not require intersubject image registration or operator-defined regions of interest, thus avoiding many pitfalls common in DTI methods.

Materials and methods

We collected 3T DTI data from 15 patients with probable NPH and 25 controls with AD, PD, or dementia with Lewy bodies. We developed a parametric model for the shape of intracranial mean diffu

SUBMITTER: Ivkovic M 

PROVIDER: S-EPMC7964573 | biostudies-literature | 2013 Jun-Jul

REPOSITORIES: biostudies-literature