No association between conventional brain MR imaging and chronic cerebrospinal venous insufficiency in multiple sclerosis.

ABSTRACT:

Background and purpose

CCSVI has been reported to occur at high frequency in MS. Its significance in relation to MR imaging parameters also needs to be determined, both in patients with MS and HCs. Therefore, this study determined the associations of CCSVI and conventional MR imaging outcomes in patients with MS and in HCs.

Materials and methods

T2, T1, and gadolinium lesion number, LV, and brain atrophy were assessed on 3T MR imaging in 301 subjects, of whom 162 had RRMS, 66 had secondary-progressive MS subtype, and 73 were HCs. CCSVI was assessed using extracranial and transcranial Doppler evaluation. The MR imaging measure differences were explored with 27 borderline cases for CCSVI, added to both the negative and positive CCSVI groups to assess sensitivity of the results

SUBMITTER: Zivadinov R 

PROVIDER: S-EPMC7964624 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature