Diffusion Tensor Imaging and Fiber Tractography in Children with Craniosynostosis Syndromes.

ABSTRACT:

Background and purpose

Patients with craniosynostosis syndromes caused by mutations in FGFR-2, FGFR-3, and TWIST1 genes are characterized by having prematurely fused skull sutures and skull base synchondroses, which result in a skull deformity and are accompanied by brain anomalies, including altered white matter microarchitecture. In this study, the reliability and reproducibility of DTI fiber tractography was investigated in these patients. The outcomes were compared with those of controls.

Materials and methods

DTI datasets were acquired with a 1.5T MR imaging system with 25 diffusion gradient orientations (voxel size = 1.8 × 1.8 × 3.0 mm(3), b-value = 1000 s/mm(2)). White matter tracts studied included the following: corpus callosum, cingulate gyrus, fornix, corticospina

SUBMITTER: Rijken BF 

PROVIDER: S-EPMC7964691 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature