Effect of age on MRI phase behavior in the subcortical deep gray matter of healthy individuals.

ABSTRACT:

Background and purpose

It has been demonstrated that increased levels of iron in the brain occur with aging. In this study we investigated the nature of the association between age and SWI-filtered phase values, indicative of iron content, in the subcortical deep gray matter of healthy individuals.

Materials and methods

A total of 210 healthy individuals (men: n = 89, women: n = 121), mean age, 39.8 years (standard deviation = 15.5; range = 6-76 years), were imaged on a 3T scanner. Mean MRI phase, mean phase of low-phase voxels, and normalized volumes were determined for total subcortical deep gray matter, caudate, putamen, globus pallidus, thalamus, pulvinar nucleus, hippocampus, amygdala, nucleus accumbens, red nucleus, and substantia nigra. Linear and nonlinear regression

SUBMITTER: Hagemeier J 

PROVIDER: S-EPMC7964836 | biostudies-literature | 2013 Nov-Dec

REPOSITORIES: biostudies-literature