Gray Matter Volume Reduction Is Associated with Cognitive Impairment in Neuromyelitis Optica.

ABSTRACT:

Background and purpose

Whether gray matter impairment occurs in neuromyelitis optica is a matter of ongoing debate, and the association of gray matter impairment with cognitive deficits remains largely unknown. The purpose of this study was to investigate gray matter volume reductions and their association with cognitive decline in patients with neuromyelitis optica.

Materials and methods

This study included 50 patients with neuromyelitis optica and 50 sex-, age-, handedness-, and education-matched healthy subjects who underwent high-resolution structural MR imaging examinations and a battery of cognitive assessments. Gray matter volume and cognitive differences were compared between the 2 groups. The correlations of the regional gray matter volume with cognitive scores and

SUBMITTER: Wang Q 

PROVIDER: S-EPMC7965033 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature