Theta Phase Synchrony Is Sensitive to Corollary Discharge Abnormalities in Early Illness Schizophrenia but Not in the Psychosis Risk Syndrome.

ABSTRACT:

Background

Prior studies have shown that the auditory N1 event-related potential component elicited by self-generated vocalizations is reduced relative to played back vocalizations, putatively reflecting a corollary discharge mechanism. Schizophrenia patients and psychosis risk syndrome (PRS) youth show deficient N1 suppression during vocalization, consistent with corollary discharge dysfunction. Because N1 is an admixture of theta (4-7 Hz) power and phase synchrony, we examined their contributions to N1 suppression during vocalization, as well as their sensitivity, relative to N1, to corollary discharge dysfunction in schizophrenia and PRS individuals.

Methods

Theta phase and power values were extracted from electroencephalography data acquired from PRS youth (n = 71), earl

SUBMITTER: Roach BJ 

PROVIDER: S-EPMC7965080 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature