Diffusion tensor analysis of pediatric multiple sclerosis and clinically isolated syndromes.

ABSTRACT:

Background and purpose

DTI has shown focal and diffuse white matter abnormalities in adults and children with MS. Here we explore whether DTI abnormalities are present at the time of a first attack or CIS in children and whether early DTI features can predict the development of MS.

Materials and methods

We assessed region-of-interest and tract-based mean ADC and mean FA values for 3 major white matter pathways and NAWM in 20 children with MS, 27 children with forms of CIS, and controls. Tracts were selected by using standard region-of-interest placements on color FA maps. Identical ROIs were placed in the NAWM on b = 0 T2-weighted images to ensure that both ROIs and resulting tracts passed through NAWM. Conventional MR imaging characteristics were assessed by visual inspecti

SUBMITTER: Vishwas MS 

PROVIDER: S-EPMC7965111 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature