Magnetization transfer imaging in premanifest and manifest huntington disease: a 2-year follow-up.

ABSTRACT:

Background and purpose

MTI is a quantitative MR imaging technique that has recently demonstrated structural integrity differences between controls and patients with HD. Potentially, MTI can be used as a biomarker for monitoring disease progression. To establish the value of MTI as a biomarker, we aimed to examine the change in these measures during the course of HD.

Materials and methods

From the Leiden TRACK-HD study, 25 controls, 21 premanifest gene carriers, and 21 patients with manifest HD participated at baseline and during a 2-year follow-up visit. Brain segmentation of the cortical gray matter, white matter, caudate nucleus, putamen, pallidum, thalamus, amygdala, and hippocampus was performed by using the automated tools FAST and FIRST in FSL. Individual MTR values we

SUBMITTER: van den Bogaard SJ 

PROVIDER: S-EPMC7965112 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature