Susceptibility-diffusion mismatch predicts thrombolytic outcomes: a retrospective cohort study.

ABSTRACT:

Background and purpose

Asymmetric hypointensity of cerebral veins on susceptibility-weighted imaging has been shown to indirectly reflect tissue hypoxia after cerebral ischemia. We therefore investigated whether patients with prominent asymmetry of the cerebral veins on SWI and a relatively small diffusion-weighted imaging lesion (SWI-DWI mismatch), representing the presence of salvageable tissue, were more likely to benefit from thrombolytic therapy.

Materials and methods

We conducted a retrospective study of the anterior circulation of patients with ischemic stroke with SWI/DWI acquired before thrombolysis. The asymmetry index was defined as the ratio of cerebral vein voxel count between the ischemic and normal hemisphere on the SWI phase map. We defined SWI-DWI mismatch a

SUBMITTER: Lou M 

PROVIDER: S-EPMC7965182 | biostudies-literature | 2014 Nov-Dec

REPOSITORIES: biostudies-literature