Cranial Nerve Abnormalities in Oculo-Auriculo-Vertebral Spectrum.

ABSTRACT:

Background and purpose

Cranial nerve abnormalities might be observed in hemifacial microsomia and microtia (oculo-auriculo-vertebral spectrum), but the rate, features, and relationship with functional impairment or phenotype severity have not yet been defined. This study aimed at investigating absence/asymmetry, abnormal origin, morphology and course of cranial nerves, and presence/asymmetry of the foramen ovale and inferior alveolar nerve canal in a cohort of oculo-auriculo-vertebral spectrum patients.

Materials and methods

Twenty-nine patients with oculo-auriculo-vertebral spectrum (mean age, 7 years; age range, 0.2-31 years; 12 females) underwent brain MR imaging, CT, and neurologic evaluation; 19 patients had a more severe phenotype (Goldenhar syndrome).

Results

C

SUBMITTER: Manara R 

PROVIDER: S-EPMC7965278 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature