Time-dependent structural changes of the dentatothalamic pathway in children treated for posterior fossa tumor.

ABSTRACT:

Background and purpose

Injury to the dentatothalamic pathway that originates in the cerebellum has been suggested as a mechanism for neurologic complications in children treated for posterior fossa tumors. We hypothesized that time-dependent changes occur in the dentatothalamic pathway.

Materials and methods

Diffusion tensor evaluation was performed in 14 children (median age, 4.1 years; age range, 1-20 years) who underwent serial MR imaging at 3T as part of routine follow-up after posterior fossa tumor resection with or without adjuvant therapy. Tensor metrics were obtained in the acute (≤1 week), subacute (1 to <6 months), and chronic (≥6 months) periods after surgery. We evaluated the following dentatothalamic constituents: bilateral dentate nuclei, cerebellar white matte

SUBMITTER: Perreault S 

PROVIDER: S-EPMC7965802 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature