Genetic correlations of brain lesion distribution in multiple sclerosis: an exploratory study.

ABSTRACT:

Background and purpose

In MS, the total brain lesion volume and spatial distribution of lesions across the brain vary widely among individual patients. We hypothesized that spatial distribution may be partially driven by genetic predisposition, and we aimed to explore relations among candidate genes and the spatial distribution of white matter brain lesions in MS.

Material and methods

Genotypes of 69 SNPs in 208 patients with MS were related to the spatial distribution of T2 brain lesions. Lesions were manually outlined on MR images, and binary lesion masks were produced and registered to a common space. With Randomise software, the lesion masks were related to genotype by using a voxelwise nonparametric GLM approach, followed by clusterwise analysis. We used a DNA chip with

SUBMITTER: Sombekke MH 

PROVIDER: S-EPMC7965886 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature