Mapping p53 mutations in low-grade glioma: a voxel-based neuroimaging analysis.

ABSTRACT:

Background and purpose

Brain tumor location has proved to be a prognostic factor that may be associated with features of neoplastic origin. Mutation of p53 is an atypical genetic change that occurs during tumorigenesis. Thus, a potential correlation may exist between tumor location and p53 status. The purpose of the current study was to identify anatomic characteristics of mutant p53 expression by using quantitative neuroimaging analyses.

Materials and methods

Preoperative MR images from 182 patients with histologically confirmed low-grade gliomas were retrospectively analyzed. All tumors were manually marked and registered to the standard space. Using a voxel-based lesion-symptom mapping analysis, we located brain regions associated with a high occurrence of p53 mutation an

SUBMITTER: Wang YY 

PROVIDER: S-EPMC7965905 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature