Altered brain activation and connectivity in early Parkinson disease tactile perception.

ABSTRACT:

Background and purpose

Deficits in tactile perception are common in patients with PD. However, the neural mechanisms have not been previously reported in the early stages. This study aims to investigate how the brain activity and connectivity changed under tactile perception at early Parkinsonian state by using functional MR imaging.

Materials and methods

Twenty-one patients with early PD and 22 age- and sex-matched controls were recruited and scanned under a passive tactile stimulation task. Within-group and between-group activation maps were acquired, and regions of interest were defined according to the group-comparison result. This was followed by a functional connectivity analysis based on the graph theory.

Results

We found that in the PD group, bilateral sensori

SUBMITTER: Cao H 

PROVIDER: S-EPMC7966011 | biostudies-literature | 2011 Nov-Dec

REPOSITORIES: biostudies-literature