Phase white matter signal abnormalities in patients with clinically isolated syndrome and other neurologic disorders.

ABSTRACT:

Background and purpose

Identifying MRI biomarkers that can differentiate multiple sclerosis patients from other neurological disorders is a subject of intense research. Our aim was to investigate phase WM signal abnormalities for their presence, prevalence, location, and diagnostic value among patients with clinically isolated syndrome and other neurologic disorders and age-, sex-, and group-matched healthy controls.

Materials and methods

Forty-eight patients with clinically isolated syndrome and 30 patients with other neurologic diseases and a healthy control group (n = 47) were included in the study. Subjects were scanned at 3T by using SWI-filtered phase and T2WI, with WM signal abnormalities ≥3 mm being classified.

Results

Patients with clinically isolated syndrom

SUBMITTER: Hagemeier J 

PROVIDER: S-EPMC7966244 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature