Alterations of Gastric Microbiota in Gastric Cancer and Precancerous Stages.

ABSTRACT:

Objective

Microbial infections have been shown to contribute to gastric carcinogenesis, the knowledge of gastric microbiota alteration in this process may provide help in early diagnosis of gastric cancer. The aim of this study was to characterize the microbial changes and identify taxonomic biomarkers across stages of gastric carcinogenesis.

Methods

The gastric microbiota was investigated by 16S rRNA gene analysis in gastric mucosal specimens from 47 patients including superficial gastritis (SG), atrophic gastritis (AG), gastric intraepithelial neoplasia (GIN), and gastric cancer (GC). Differences in microbial composition across the disease stages, especially in GIN and GC were assessed using linear discriminant analysis effect size.

Results

There was no gradual chan

SUBMITTER: Zhang X 

PROVIDER: S-EPMC7966516 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature