Identification of Stemness Characteristics Associated With the Immune Microenvironment and Prognosis in Gastric Cancer.

ABSTRACT:

Background

Gastric cancer (GC) is a highly heterogeneous disease. In recent years, the prognostic value of the mRNA expression-based stemness index (mRNAsi) across cancers has been reported. We intended to identify stemness index-associated genes (SI-genes) for clinical characteristic, gene mutation status, immune response, and tumor microenvironment evaluation as well as risk stratification and survival prediction.

Methods

The correlations between the mRNAsi and GC prognosis, clinical characteristics, gene mutation status, immune cell infiltration and tumor microenvironment were evaluated. Weighted gene correlation network analysis (WGCNA) was performed to identify SI-genes from differentially expressed genes (DEGs) in The Cancer Genome Atlas (TCGA). Single-sample gene set

SUBMITTER: Mao D 

PROVIDER: S-EPMC7966731 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature