Isotope pattern deconvolution as a successful alternative to calibration curve for application in wastewater-based epidemiology.

ABSTRACT: An isotope pattern deconvolution (IPD) quantification method has been applied for the determination of five substances (amphetamine, benzoylecgonine, cocaine, methamphetamine and MDMA) in wastewater for the application in wastewater-based epidemiology (WBE). A previously validated method that used a calibration curve for quantification was modified to apply IPD. The two approaches were compared in terms of analytical uncertainty in recovery studies of quality control samples, i.e. six wastewater samples from different geographical origins spiked at two concentration levels. Both methods were reliable as they passed (z-score < 2) in an interlaboratory exercise. After 60 individual determinations, IPD provided 11 results outside recovery limits (70-120%) while the previous method produced 31

SUBMITTER: Pitarch-Motellon J 

PROVIDER: S-EPMC7966919 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature