Effect of Marine Omega-3 Fatty Acid and Vitamin D Supplementation on Incident Atrial Fibrillation: A Randomized Clinical Trial.

ABSTRACT:

Importance

Atrial fibrillation (AF) is the most common heart rhythm disturbance, continues to increase in incidence, and results in significant morbidity and mortality. The marine omega-3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and vitamin D have been reported to have both benefits and risks with respect to incident AF, but large-scale, long-term randomized trial data are lacking.

Objective

To test the effects of long-term administration of marine omega-3 fatty acids and vitamin D on incident AF.

Design, setting, and participants

An ancillary study of a 2 × 2 factorial randomized clinical trial involving 25 119 women and men aged 50 years or older without prior cardiovascular disease, cancer, or AF. Participants were recruited directly

SUBMITTER: Albert CM 

PROVIDER: S-EPMC7967086 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature