Novel therapeutics for the treatment of hypertension and its associated complications: peptide- and nonpeptide-based strategies.

ABSTRACT: The renin-angiotensin-aldosterone system (RAAS) is responsible for maintaining blood pressure and vascular tone. Modulation of the RAAS, therefore, interferes with essential cellular processes and leads to high blood pressure, oxidative stress, inflammation, fibrosis, and hypertrophy. Consequently, these conditions cause fatal cardiovascular and renal complications. Thus, the primary purpose of hypertension treatment is to diminish or inhibit overactivated RAAS. Currently available RAAS inhibitors have proven effective in reducing blood pressure; however, beyond hypertension, they have failed to treat end-target organ injury. In addition, RAAS inhibitors have some intolerable adverse effects, such as hyperkalemia and hypotension. These gaps in the available treatment for hypertension requi

SUBMITTER: Ghatage T 

PROVIDER: S-EPMC7967108 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature