Increased Presence of Complement Factors and Mast Cells in Alveolar Bone and Tooth Resorption.

ABSTRACT: Periodontitis is the inflammatory destruction of the tooth-surrounding and -supporting tissue, resulting at worst in tooth loss. Another locally aggressive disease of the oral cavity is tooth resorption (TR). This is associated with the destruction of the dental mineralized tissue. However, the underlying pathomechanisms remain unknown. The complement system, as well as mast cells (MCs), are known to be involved in osteoclastogenesis and bone loss. The complement factors C3 and C5 were previously identified as key players in periodontal disease. Therefore, we hypothesize that complement factors and MCs might play a role in alveolar bone and tooth resorption. To investigate this, we used the cat as a model because of the naturally occurring high prevalence of both these disorders in this sp

SUBMITTER: Luntzer K 

PROVIDER: S-EPMC7967164 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature