Changes in Metabolic Syndrome Status and Breast Cancer Risk: A Nationwide Cohort Study.

ABSTRACT:

Objective

To our knowledge, no studies have yet looked at how the risk of developing breast cancer (BC) varies with changes in metabolic syndrome (MetS) status. This study aimed to investigate the association between changes in MetS and subsequent BC occurrence.

Research design and methods

We enrolled 930,055 postmenopausal women aged 40-74 years who participated in a biennial National Health Screening Program in 2009-2010 and 2011-2012. Participants were categorized into four groups according to change in MetS status during the two-year interval screening: sustained non-MetS, transition to MetS, transition to non-MetS, and sustained MetS. We calculated multivariable-adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for BC incidence using the Cox proportional

SUBMITTER: Choi IY 

PROVIDER: S-EPMC7967214 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature