Astrocytic Tau Deposition Is Frequent in Typical and Atypical Alzheimer Disease Presentations.

ABSTRACT: Typical Alzheimer disease (AD) features an amnestic syndrome that reflects the progression of pathology through specific neural networks. However, a subset of patients exhibits atypical onset with prominent language, behavioral, or visuospatial deficits that are not explained by current neuropathological staging schemes. Astrogliopathy featuring tau inclusions with thorn-shaped and granular fuzzy morphologies is common in the aging brain and collectively known as aging-related tau astrogliopathy (ARTAG). Prior studies have identified tau-positive thorn-shaped astrocytes in the white matter that associate with a primary progressive aphasia phenotype in an AD cohort. However, a possible contribution of ARTAG copathology to AD clinical heterogeneity has yet to be systematically examined. To i

SUBMITTER: Nolan A 

PROVIDER: S-EPMC7967845 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature