Resveratrol protects against high glucose-induced oxidative damage in human lens epithelial cells by activating autophagy.

ABSTRACT: In the pathogenesis of diabetic cataract, high glucose levels induce oxidative damage in human lens epithelial cells (HLECs). Resveratrol has been demonstrated to be a potent antioxidant in various disease conditions; however, limited information is available on its effects on oxidative damage associated with the pathogenesis of diabetic cataract in HLECs. The present study aimed to determine whether resveratrol prevents high glucose-induced oxidative damage to human lens epithelial cells by activating autophagy. In the present study, HLECs treated with high glucose were used as a cellular model of diabetic cataract and treated with resveratrol for 24 h. Flow cytometry was performed to detect the cellular reactive oxygen species (ROS) content. Autophagy marker protein levels were determine

SUBMITTER: Chen P 

PROVIDER: S-EPMC7967869 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature