Subglottic stenosis and endobronchial disease in granulomatosis with polyangiitis.

ABSTRACT:

Objectives

To describe tracheobronchial disease in patients with granulomatosis with polyangiitis (GPA) and evaluate the utility of dynamic expiratory CT to detect large-airway disease.

Methods

Demographic and clinical features associated with the presence of subglottic stenosis (SGS) or endobronchial involvement were assessed in a multicentre, observational cohort of patients with GPA. A subset of patients with GPA from a single-centre cohort underwent dynamic chest CT to evaluate the airways.

Results

Among 962 patients with GPA, SGS and endobronchial disease were identified in 95 (10%) and 59 (6%) patients, respectively. Patients with SGS were more likely to be female (72% vs 53%, P < 0.01), younger at time of diagnosis (36 vs 49 years, P < 0.01), and have saddle-no

SUBMITTER: Quinn KA 

PROVIDER: S-EPMC7967893 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature