EZH2 and SMYD3 expression in papillary thyroid cancer.

ABSTRACT: Recent studies have revealed the significant role of SMYD3 and EZH2 genes in the development and aggressiveness of numerous types of malignant tumor. Therefore, the present study aimed to investigate the expression of SMYD3 and EZH2 in papillary thyroid cancer, and to determine the correlation between the expression of these genes and clinical characteristics. Resected thyroid tissue samples from 62 patients with papillary thyroid cancer were investigated. Thyroid tissue derived from the healthy regions of removed nodular goiters from 30 patients served as the control group. Reverse transcription-quantitative PCR analysis was employed to detect relative mRNA expression levels. Primer sequences and TaqMan^® hydrolysis probe positions for EZH2 and

SUBMITTER: Sawicka-Gutaj N 

PROVIDER: S-EPMC7967944 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature