Dataset Information

Understanding patient journey in ulcerative colitis prior to biologic initiation: a 5-year exploration.

ABSTRACT:

Background

There has been a more pronounced shift toward earlier, more aggressive therapies in Crohn's disease than in ulcerative colitis (UC). The aim of this study was to describe the pre-biologic treatment and health care experience, including co-morbidities and overall health care utilization, for UC patients who initiated biologic therapies, in the 5 years prior to the initiation of the first biologic agent.

Methods

UC patients who initiated a biologic agent approved for UC between 9/15/2005 and 1/30/2018 were identified from the IBM® MarketScan® Commercial Database, a large US database. The date of the first recorded UC biologic exposure was defined as the index date, and ≥ 5 years of pre-index records were required to evaluate patients' treatment, disease progression and overall health care utilization prior to initiating biologic agents.

Results

Among the 1891 eligible patients, treatment with oral corticosteroids, 5-aminosalicylates, and other non-biologic immunomodulators, all increased progressively across the 5 years prior to the index. From within year-five to within year-one prior to the index, the median duration of oral corticosteroid treatment increased from 34 to 88 days per year and the proportion of patients who experienced more extensive/pancolitis disease increased from 16 to 59%. Overall, the frequency of all-cause health care visits also increased.

Conclusions

Patients with UC experienced increasing morbidity and treatment burden in the 5 years prior to initiating biologic therapy. To achieve reduced corticosteroids in UC management, better risk stratification is needed to help identify patients for more timely biologic treatment.

SUBMITTER: Wang Y

PROVIDER: S-EPMC7967955 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature

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Publications

Understanding patient journey in ulcerative colitis prior to biologic initiation: a 5-year exploration.

Wang Yiting Y Makadia Rupa R Knoll Christopher C Hardin Jill J Voss Erica A EA Fife Daniel D Davis Kourtney K Sloan Sheldon S

BMC gastroenterology 20210317 1

<h4>Background</h4>There has been a more pronounced shift toward earlier, more aggressive therapies in Crohn's disease than in ulcerative colitis (UC). The aim of this study was to describe the pre-biologic treatment and health care experience, including co-morbidities and overall health care utilization, for UC patients who initiated biologic therapies, in the 5 years prior to the initiation of the first biologic agent.<h4>Methods</h4>UC patients who initiated a biologic agent approved for UC b ...[more]

PMID: 33731009

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Dataset Information

Understanding patient journey in ulcerative colitis prior to biologic initiation: a 5-year exploration.

Background

Methods

Results

Conclusions

Publications

Understanding patient journey in ulcerative colitis prior to biologic initiation: a 5-year exploration.

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