Challenges, facilitators and barriers to screening study participants in early disease stages-experience from the MACUSTAR study.

ABSTRACT:

Background

Recruiting asymptomatic participants with early disease stages into studies is challenging and only little is known about facilitators and barriers to screening and recruitment of study participants. Thus we assessed factors associated with screening rates in the MACUSTAR study, a multi-centre, low-interventional cohort study of early stages of age-related macular degeneration (AMD).

Methods

Screening rates per clinical site and per week were compiled and applicable recruitment factors were assigned to respective time periods. A generalized linear mixed-effects model including the most relevant recruitment factors identified via in-depth interviews with study personnel was fitted to the screening data. Only participants with intermediate AMD were considered.

Re

SUBMITTER: Terheyden JH 

PROVIDER: S-EPMC7967977 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature