Associations between habitual diet, metabolic disease, and the gut microbiota using latent Dirichlet allocation.

ABSTRACT:

Background

The gut microbiome impacts human health through various mechanisms and is involved in the development of a range of non-communicable diseases. Diet is a well-known factor influencing microbe-host interaction in health and disease. However, very few findings are based on large-scale analysis using population-based studies. Our aim was to investigate the cross-sectional relationship between habitual dietary intake and gut microbiota structure in the Cooperative Health Research in the Region of Augsburg (KORA) FF4 study.

Results

Fecal microbiota was analyzed using 16S rRNA gene amplicon sequencing. Latent Dirichlet allocation (LDA) was applied to samples from 1992 participants to identify 20 microbial subgroups within the study population. Each participant's gut micr

SUBMITTER: Breuninger TA 

PROVIDER: S-EPMC7967986 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature