Pentagalloyl glucose (PGG) partially prevents arterial mechanical changes due to elastin degradation.

ABSTRACT:

Background

Elastic fibers are composed primarily of the protein elastin and they provide reversible elasticity to the large arteries. Degradation of elastic fibers is a common histopathology in aortic aneurysms. Pentagalloyl glucose (PGG) has been shown to bind elastin and stabilize elastic fibers in some in vitro studies and in vivo models of abdominal aortic aneurysms, however its effects on native arteries are not well described.

Objective

Perform detailed studies of the biomechanical effects of PGG on native arteries and the preventative capabilities of PGG for elastin degraded arteries.

Methods

We treated mouse carotid arteries with PGG, elastase (ELA), and PGG+ELA and compared the wall structure, solid mechanics, and fluid transport properties to untreated (UNT)

SUBMITTER: Pavey SN 

PROVIDER: S-EPMC7968080 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature