Sex differences in CSF biomarkers for neurodegeneration and blood-brain barrier integrity.

ABSTRACT:

Introduction

As cerebrospinal fluid (CSF) neurofilament light protein (NfL) and the CSF/serum albumin ratio (Q_Alb) are used in the clinical routine, the impact of demographic factors on these biomarkers is important to understand.

Methods

Participants were derived from two Swedish samples: the population-based H70 Study (n = 308, age 70) and a clinical routine cohort (CSF NfL, n = 8995, Q_Alb, n = 39252, age 0 to 95). In the population-based study, Q_Alb and NfL were examined in relation to sex, cardiovascular risk factors, and cerebral white matter lesions (WMLs). In the clinical cohort, Q_Alb and NfL sex differences were tested in relation to age.

Results

Men had higher Q_Alb and NfL concentrations and had higher Q<

SUBMITTER: Skillback T 

PROVIDER: S-EPMC7968119 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature