Association of CSF Alzheimer's disease biomarkers with postoperative delirium in older adults.

ABSTRACT:

Introduction

The interaction between delirium and dementia is complex. We examined if Alzheimer's disease (AD) biomarkers in patients without clinical dementia are associated with increased risk of postoperative delirium, and whether AD biomarkers demonstrate a graded association with delirium severity.

Methods

Participants (n = 59) were free of clinical dementia, age ≥ 70 years, and scheduled for elective total knee or hip arthroplasties. Cerebrospinal fluid (CSF) was collected at the time of induction for spinal anesthesia. CSF AD biomarkers were measured by enzyme-linked immunosorbent assay (ELISA) (ADX/Euroimmun); cut points for amyloid, tau, and neurodegeneration (ATN) biomarker status were A = amyloid beta (Aβ)₄₂ <175 pg/mL or Aβ_42/40

SUBMITTER: Fong TG 

PROVIDER: S-EPMC7968120 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature