O-GlcNAcylation homeostasis controlled by calcium influx channels regulates multiple myeloma dissemination.

ABSTRACT:

Background

Multiple myeloma (MM) cell motility is a critical step during MM dissemination throughout the body, but how it is regulated remains largely unknown. As hypercalcemia is an important clinical feature of MM, high calcium (Ca²⁺) and altered Ca²⁺ signaling could be a key contributing factor to the pathological process.

Methods

Bioinformatics analyses were employed to assess the clinical significance of Ca²⁺ influx channels in clinical specimens of smoldering and symptomatic MM. Functional and regulatory roles of influx channels and downstream signaling in MM cell migration and invasion were conducted and experimental MM dissemination was examined in a xenograft mouse model using in vivo live imaging and engraftment analysis.

Results

SUBMITTER: Samart P 

PROVIDER: S-EPMC7968185 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature