Effects of sevoflurane anesthesia and abdominal surgery on the systemic metabolome: a prospective observational study.

ABSTRACT:

Background

Metabolic status can be impacted by general anesthesia and surgery. However, the exact effects of general anesthesia and surgery on systemic metabolome remain unclear, which might contribute to postoperative outcomes.

Methods

Five hundred patients who underwent abdominal surgery were included. General anesthesia was mainly maintained with sevoflurane. The end-tidal sevoflurane concentration (ET_sevo) was adjusted to maintain BIS (Bispectral index) value between 40 and 60. The mean ET_sevo from 20 min after endotracheal intubation to 2 h after the beginning of surgery was calculated for each patient. The patients were further divided into low ET_sevo group (mean - SD) and high ET_sevo group (mean + SD) to investigate the poss

SUBMITTER: Wei Y 

PROVIDER: S-EPMC7968205 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature