A meta-analysis and systematic review on subtypes of gastric intestinal metaplasia and neoplasia risk.

ABSTRACT:

Background

Gastric intestinal metaplasia (GIM) is a significant risk factor for gastric cancer. Risk of gastric cancer/dysplasia between complete intestinal metaplasia (CIM) and incomplete intestinal metaplasia (IIM) was controversial. Our study aimed to pool relative risk (RR) of cancer/dysplasia of IIM compared with CIM in GIM patients.

Methods

PubMed, EMBASE, Cochrane Library and Web of Science were searched for studies concerning cancer/dysplasia in GIM patients. Random-effects or fixed-effects model was utilized for pooling RR. Sensitivity and publication bias analyses were conducted. Stability of results would be evaluated in case of publication bias.

Results

12 studies were included. Compared with CIM, pooled RR of cancer/dysplasia in IIM patients was 4.48 (95%

SUBMITTER: Wei N 

PROVIDER: S-EPMC7968216 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature