Additive interaction of mid- to late-life depression and cerebrovascular disease on the risk of dementia: a nationwide population-based cohort study.

ABSTRACT:

Background

Dementia is a progressive neurocognitive disease with a substantial social burden. No apparent breakthroughs in treatment options have emerged so far; thus, disease prevention is essential for at-risk populations. Depression and cerebrovascular disease (CVD) are independent risk factors for dementia, but no studies have examined their interaction effect on dementia risk. This study aimed to identify the association of depression and CVD with the risk of dementia and evaluate whether dementia risk among patients with comorbid depression and CVD is higher than the sum of the individual risk due to each condition.

Methods

A population-based cohort study was conducted to analyze the Korean National Health Insurance Service-National Sample Cohort data of all individual

SUBMITTER: Jang YJ 

PROVIDER: S-EPMC7968260 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature