Thyroid-stimulating hormone decreases the risk of osteoporosis by regulating osteoblast proliferation and differentiation.

ABSTRACT:

Background

As the incidence of secretory osteoporosis has increased, bone loss, osteoporosis and their relationships with thyroid-stimulating hormone (TSH) have received increased attention. In this study, the role of TSH in bone metabolism and its possible underlying mechanisms were investigated.

Methods

We analyzed the serum levels of free triiodothyronine (FT3), free thyroxine (FT4), and TSH and the bone mineral density (BMD) levels of 114 men with normal thyroid function. In addition, osteoblasts from rat calvarial samples were treated with different doses of TSH for different lengths of time. The related gene and protein expression levels were investigated.

Results

A comparison of the BMD between the high-level and low-level serum TSH groups showed that the TSH s

SUBMITTER: Deng T 

PROVIDER: S-EPMC7968288 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature