Enhanced lung inflammatory response in whole-body compared to nose-only cigarette smoke-exposed mice.

ABSTRACT:

Background

Chronic obstructive pulmonary disease (COPD) is characterized by a progressive and abnormal inflammatory response in the lungs, mainly caused by cigarette smoking. Animal models exposed to cigarette smoke (CS) are used to mimic human COPD but the use of different CS protocols makes it difficult to compare the immunological and structural consequences of using a nose-only or whole-body CS exposure system. We hypothesized that when using a standardized CS exposure protocol based on particle density and CO (carbon monoxide) levels, the whole-body CS exposure system would generate a more severe inflammatory response than the nose-only system, due to possible sensitization by uptake of CS-components through the skin or via grooming.

Methods

In this study focusing on ea

SUBMITTER: Serre J 

PROVIDER: S-EPMC7968299 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature