Long non-coding RNA MALAT1 regulates cell proliferation and apoptosis via miR-135b-5p/GPNMB axis in Parkinson's disease cell model.

ABSTRACT:

Backgrounds

Parkinson's disease (PD) is a common age-related neurodegenerative disorder worldwide. This research aimed to investigate the effects and mechanism underlying long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in PD.

Methods

SK-N-SH and SK-N-BE cells were treated with MPP⁺ to establish the MPP⁺-stimulated cell model of PD, and MALAT1 expression was determined. Then, the effects of MALAT1 depletion on cell proliferation and apoptosis were determined in the MPP⁺-stimulated cell model of PD. Besides, the correlations between microRNA-135b-5p (miR-135b-5p) and MALAT1 or glycoprotein nonmetastatic melanoma protein B (GPNMB) in MPP⁺-stimulated cell model of PD were explored.

Results

MAL

SUBMITTER: Lv K 

PROVIDER: S-EPMC7968316 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature