Genomic Profiling Identified Novel Prognostic Biomarkers in Chinese Midline Glioma Patients.

ABSTRACT:

Background

Molecular characteristics are essential for the classification and grading of gliomas. However, diagnostic classification of midline glioma is still debatable and substantial molecular and clinical heterogeneity within each subgroup suggested that they should be further stratified. Here, we studied the mutation landscape of Chinese midline glioma patients in hope to provide new insights for glioma prognosis and treatment.

Methods

Tissue samples from 112 midline glioma patients underwent next-generation sequencing targeting 425 cancer-relevant genes. Gene mutations and copy number variations were investigated for their somatic interactions and prognostic effect using overall survival data. Pathway-based survival analysis was performed for ten canonical oncogenic pa

SUBMITTER: Li H 

PROVIDER: S-EPMC7968371 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature