Individual Oligodendrocytes Show Bias for Inhibitory Axons in the Neocortex.

ABSTRACT: Reciprocal communication between neurons and oligodendrocytes is essential for the generation and localization of myelin, a critical feature of the CNS. In the neocortex, individual oligodendrocytes can myelinate multiple axons; however, the neuronal origin of the myelinated axons has remained undefined and, while largely assumed to be from excitatory pyramidal neurons, it also includes inhibitory interneurons. This raises the question of whether individual oligodendrocytes display bias for the class of neurons that they myelinate. Here, we find that different classes of cortical interneurons show distinct patterns of myelin distribution starting from the onset of myelination, suggesting that oligodendrocytes can recognize the class identity of individual types of interneurons that they ta

SUBMITTER: Zonouzi M 

PROVIDER: S-EPMC7968376 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature