Macrophage HIF-1α Is an Independent Prognostic Indicator in Kidney Cancer.

ABSTRACT:

Purpose

Clear cell renal cell carcinoma (ccRCC) is frequently associated with inactivation of the von Hippel-Lindau tumor suppressor, resulting in activation of HIF-1α and HIF-2α. The current paradigm, established using mechanistic cell-based studies, supports a tumor promoting role for HIF-2α, and a tumor suppressor role for HIF-1α. However, few studies have comprehensively examined the clinical relevance of this paradigm. Furthermore, the hypoxia-associated factor (HAF), which regulates the HIFs, has not been comprehensively evaluated in ccRCC.

Experimental design

To assess the involvement of HAF/HIFs in ccRCC, we analyzed their relationship to tumor grade/stage/outcome using tissue from 380 patients, and validated these associations using tissue from 72 additional patient

SUBMITTER: Cowman SJ 

PROVIDER: S-EPMC7968518 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature