Molecular epidemiology of Mycobacterium tuberculosis complex in the Volta Region of Ghana.

ABSTRACT:

Context

Available molecular epidemiological data from recent studies suggest significant genetic variation between the different lineages of Mycobacterium tuberculosis complex (MTBC) and the MTBC lineages might have adapted to different human populations.

Aim

This study sought to determine the population structure of clinical MTBC isolates from the Volta Region of Ghana.

Methods

The MTBC isolates obtained from collected sputum samples were identified by PCR detecting of IS6110 and genotyped using spoligotyping. Non-tuberculous mycobacterial isolates were characterized by amplification of the heat shock protein 65 (hsp65) gene and sequencing. The drug susceptibility profiles of the MTBCs determined using GenoType MTBDRplus.

Results

One hundred and seventeen (117

SUBMITTER: Ameke S 

PROVIDER: S-EPMC7968653 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature