Membrane particles from mesenchymal stromal cells reduce the expression of fibrotic markers on pulmonary cells.

ABSTRACT:

Background

Idiopathic pulmonary fibrosis (IPF) is a devastating lung disease with limited treatment options in which the telomere shortening is a strong predictive factor of poor prognosis. Mesenchymal stromal cells (MSC) administration is probed in several experimental induced lung pathologies; however, MSC might stimulate fibrotic processes. A therapy that avoids MSC side effects of transformation would be an alternative to the use of living cells. Membranes particles (MP) are nanovesicles artificially generated from the membranes of MSC containing active enzymes involved in ECM regeneration. We aimed to investigate the anti-fibrotic role of MP derived from MSC in an in vitro model of pulmonary fibrosis.

Methods

Epithelial cells (A549) and lung fibroblasts, from IPF patien

SUBMITTER: Merino A 

PROVIDER: S-EPMC7968667 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature