Extracellular matrix density regulates the formation of tumour spheroids through cell migration.

ABSTRACT: In this work, we show how the mechanical properties of the cellular microenvironment modulate the growth of tumour spheroids. Based on the composition of the extracellular matrix, its stiffness and architecture can significantly vary, subsequently influencing cell movement and tumour growth. However, it is still unclear exactly how both of these processes are regulated by the matrix composition. Here, we present a centre-based computational model that describes how collagen density, which modulates the steric hindrance properties of the matrix, governs individual cell migration and, consequently, leads to the formation of multicellular clusters of varying size. The model was calibrated using previously published experimental data, replicating a set of experiments in which cells were seeded

SUBMITTER: Goncalves IG 

PROVIDER: S-EPMC7968691 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature