Forecasting seizure risk in adults with focal epilepsy: a development and validation study.

ABSTRACT:

Background

People with epilepsy are burdened with the apparent unpredictability of seizures. In the past decade, converging evidence from studies using chronic EEG (cEEG) revealed that epileptic brain activity shows robust cycles, operating over hours (circadian) and days (multidien). We hypothesised that these cycles can be leveraged to estimate future seizure probability, and we tested the feasibility of forecasting seizures days in advance.

Methods

We did a feasibility study in distinct development and validation cohorts, involving retrospective analysis of cEEG data recorded with an implanted device in adults (age ≥18 years) with drug-resistant focal epilepsy followed at 35 centres across the USA between Jan 19, 2004, and May 18, 2018. Patients were required to have had

SUBMITTER: Proix T 

PROVIDER: S-EPMC7968722 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature