Three-dimensional, multifunctional neural interfaces for cortical spheroids and engineered assembloids.

ABSTRACT: Three-dimensional (3D), submillimeter-scale constructs of neural cells, known as cortical spheroids, are of rapidly growing importance in biological research because these systems reproduce complex features of the brain in vitro. Despite their great potential for studies of neurodevelopment and neurological disease modeling, 3D living objects cannot be studied easily using conventional approaches to neuromodulation, sensing, and manipulation. Here, we introduce classes of microfabricated 3D frameworks as compliant, multifunctional neural interfaces to spheroids and to assembloids. Electrical, optical, chemical, and thermal interfaces to cortical spheroids demonstrate some of the capabilities. Complex architectures and high-resolution features highlight the design versatility. Detailed stud

SUBMITTER: Park Y 

PROVIDER: S-EPMC7968849 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature