Ontology highlight
ABSTRACT:
SUBMITTER: Fan X
PROVIDER: S-EPMC7968925 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Fan Xiaochen X Masamsetti V Pragathi VP Sun Jane Qj JQ Engholm-Keller Kasper K Osteil Pierre P Studdert Joshua J Graham Mark E ME Fossat Nicolas N Tam Patrick Pl PP
eLife 20210208
Protein interaction is critical molecular regulatory activity underlining cellular functions and precise cell fate choices. Using TWIST1 BioID-proximity-labeling and network propagation analyses, we discovered and characterized a TWIST-chromatin regulatory module (TWIST1-CRM) in the neural crest cells (NCC). Combinatorial perturbation of core members of TWIST1-CRM: TWIST1, CHD7, CHD8, and WHSC1 in cell models and mouse embryos revealed that loss of the function of the regulatory module resulted ...[more]