Association between Histone Deacetylase 9 Gene Polymorphism and Stroke in Chinese Han Population.

ABSTRACT:

Objective

To explore the correlation between the polymorphism of histone deacetylase 9 gene (rs1060499865, rs723296, rs957960) and ischemic stroke (IS) in Chinese Han population in Dali region.

Methods

This study included 155 IS patients and 128 healthy physical examinees. TaqMan-polymerase chain reaction technology and multivariate logistic regression were performed.

Results

In the case group, there was no polymorphism of rs1060499865 observed in the two groups; whereas on the rs723296 locus the frequencies of C allele and TC genotype were significantly higher than that in the control group, alleles C and T were associated with a 2.158-fold increase in IS risk, and genotypes TC and TT were associated with a 2.269-fold increase in IS risk. The locus rs957960 exhibited

SUBMITTER: Yang X 

PROVIDER: S-EPMC7969036 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature